Vilitra 20 mg (Vardenafil)

Different medicines use a diverse range of chemicals and highly specific molecules like PDE5, in the case of Vardenafil 20 mg. The molecules are made up of different functional groups in a carbon chain. Certain drugs can interact with each other this way and neutralize the effect of the drug completely. Therefore, Vardenafil 20 mg should not be taken with drugs that can change its mechanism or interact with its function in any way.

These are some common drugs that interact with Vardenafil 20 mg:

• Dangerous with nitrates or "poppers": (Nitrates e.g., nitroglycerin, isosorbide; recreational drugs like "poppers" e.g., amyl or butyl nitrite). It can cause a serious drop in blood pressure, leading to dizziness, fainting, heart attack, or stroke.
• Alpha-blockers for BPH/high blood pressure: (Alpha-blockers e.g., doxazosin, tamsulosin). It can cause blood pressure to drop too low, leading to dizziness or fainting. Doctors may lower the vardenafil dose to reduce the risk of low blood pressure.
• Drugs affecting vardenafil removal: (Azole antifungals e.g., itraconazole, ketoconazole; macrolide antibiotics e.g., clarithromycin, erythromycin; HIV protease inhibitors e.g., indinavir, ritonavir). It can affect how vardenafil is removed from the body, impacting its effectiveness.

Avoid Combined Use with Other ED Drugs

Combined use of PDE-5 medicines with other PDE-5 drugs can cause numerous health complications. The combined effect of two or more ED drugs might inhibit each other’s effect or double the same effect in the body.

For instance, you took two ED drugs at the same time. Both drugs lower your blood pressure as a symptom. You’ll likely experience extremely common side effects and higher chances of severe side effects like heart attack, stroke, and loss of special senses. Thus, combined use of such drugs should be avoided altogether.

Here's the effect of the combined use of Vardenafil 20 mg with other ED drugs.

• Sildenafil (Viagra): Severe hypotension; both are PDE5 inhibitors, increasing the risk of a significant blood pressure drop.
• Tadalafil (Cialis): Excessive blood pressure drop, with a risk of developing priapism.
• Avanafil (Spedra): Heightened risk of low blood pressure and dizziness; fast-acting PDE5 inhibitors can cause an excessive BP drop.
• Other PDE5 inhibitors: Risk of cumulative effects leading to low blood pressure and headaches; all share a similar mechanism of action.

Vilitra 20 mg or Vardenafil is a small molecule having the chemical formula C23H32N6O4S. It is a very specific inhibitor of cGMP (Cyclic Guanosine Monophosphate) and specific PDE-5.

The mechanism of action of Vilitra 20 mg is very similar to that of Viagra (Sildenafil). It's as follows:

• The Corpus cavernosum releases NO (Nitric Oxide) during sexual stimulation, activating the enzyme Guanylate Cyclase (GC).
• The activation of GC increases cGMP synthesis in smooth muscle cells of the corpus cavernosum.
• Vardenafil 20 mg, a PDE-5, inhibits the degradation of cGMP, which allows increasing flow of blood to the penis and making it erect for a few hours.

Vardenafil acts much like Sildenafil and Tadalafil but is a stronger PDE-5 in comparison.

Generic Vilitra 20 mg can be taken with or without food and drinks. It's recommended to take the drug on an empty stomach with water. Take a look at the drug’s interaction with different food types:

Generic Levitra 20 mg with Fatty Foods

Eating food items that are high in fat, such as meat and cheese,  delays the absorption of generic Levitra 20 mg. In a study, it was found that high-fat foods alter Cmax slightly and delay the absorption up to 60 mins.

Generic Levitra 20 mg with Alcohol

Alcohol consumption along with generic Levitra 20 mg is not recommended. If you take alcohol with the drug, you’ll have higher chances of lowering your blood pressure. The combined effect can cause serious hypotension. Thus, the hypotension will cause even greater side-effects, and life-threatening consequences.

Mixing alcohol with Vardenafil 20 mg can also put the heart through strain, eventually leading to cardiovascular issues. Therefore, you must not take alcohol and any ED treatment drug together as a general precaution.

Generic Levitra 20 mg with Grapefruit Juice

Grapefruits and grapefruit juice are not recommended to be used alongside any ED drug. This is because grapefruit juice interacts with liver and intestine enzymes, including CYP3A4 (Cytochrome P450 3A4). This enzyme is responsible for the breakdown of Generic Levitra 20 mg in the blood.

However, the interference of grapefruit juice blocks this enzyme, and the drug isn't metabolized properly. Therefore, higher levels of Vardenafil 20 mg remain in the blood for a longer period of time than normal. This causes an increase in longevity of many side-effects.

Read the following guidelines thoroughly to learn how to store Vilitra 20 mg best:

• Store at a dry place devoid of moisture.
• Do not flush or pour the drug down the drain unless instructed to do so.
• Keep it away from direct sunlight.
• Discard the medicine properly when you don't need it anymore or when it's expired.
• Do not keep it in the bathroom.
• Make sure to keep the drug away from the reach of children and pets.