Valif 20 mg

Generic Valif 20 mg is an oral prescription medication. The medication is taken on an empty stomach for best results. However, it is not prohibited to take food along with the medication. Here are some instructions you should follow regarding this:

• Swallow the pill with water instead of any other liquid.
• Take it with or without food (but it should be low in calories and light on the stomach).
• Use the medication at least 60 minutes before sexual activity.
• Wait 24 hours before taking another Valif 20 mg tablet/dose.

Erectile dysfunction drugs are designed to enhance erection for a considerable period of time. Typically, Valif 20 mg starts to take effect within 30-60 minutes after taking the drug. After that, the erection-promoting action of the pill lasts for about 5-7 hours.

It should be noted that the erection effect depends on sexual stimulation. Without sexual stimulation, Vardenafil 20 mg will not work and its benefit will be wasted.

Drug interactions between two or more substances cause their toxicity to change. Essentially, the drugs become harmful to the body or lose their effects altogether. According to a 2022 report, there were approximately 245,000 hospitalizations in the US due to unprecedented drug interactions. Since Valif 20 mg is an ED drug, it interacts with many other drugs. Some of these are:

• HIV and hepatitis drugs (serious) – causes hypotension.
• Itraconazole (serious) – inhibits liver enzymes, which affects blood pressure and heart rate and prolongs QT intervals.
• Ritonavir (serious) – prevents the breakdown of Vardenafil by inhibiting liver enzymes, which causes it to build up.
• Nitrates (serious) – causes blood pressure complications.
• Amiodarone (serious) – this causes a prolonged QT interval.
• Quinidine (serious) – the combination is not recommended due to potential serious interactions.
• Efavirenz (serious): increases QT levels and slows the metabolism of Vardenafil.
• Clarithromycin (serious): increases Vardenafil levels in the blood, making it more difficult for the body to eliminate it.
• Indinavir (serious): simultaneous use with Valif 20 mg lowers the amount of Indinavir in the blood.
• Ketoconazole (serious): increases drug concentrations, increasing the risk of side effects.
• Procainamide (serious): this drug should not be combined.
• Riociguat (serious): may cause dangerous hypotension.
• Antihypertensives (moderate): enhance the effects of Atenolol and could prolong the QT interval, which poses a health risk.

All ED medications belong to the class of PDE-5 inhibitors. These medications should not be used together because they can dramatically increase side effects. Common side effects will be intensified, while there will be an increased risk of serious side effects such as heart attack and loss of vision and hearing.

Apart from that, Vardenafil 20 mg is not recommended for use with medications that cause a decrease in blood pressure. All ED medications lower blood pressure. Therefore, if you use two or more ED medications at the same time, you will be at risk of severe hypotension that could also lead to death.

Other PDE-5 inhibitors that you should avoid using together or with Valif 20 mg are:

• Cialis (Tadalafil) – FDA approved
• Viagra (Sildenafil) – FDA approved
• Avanafil (Spedra) – FDA approved
• Kamagra – not FDA approved

The way Valif 20mg works is remarkably simple:

1. PDE-5 Inhibition: Vardenafil is a particular PDE-5 blocker that is present in the smooth muscle cells of the penile area.
2. cGMP Preservation: cGMP is one of the messengers of NO (nitric oxide). Due to the inhibition of PDE-5, Vardenafil has blocked the degeneration/breakdown of cGMP.
3. Vasodilation: Vardenafil increases the time taken for NO to act as a vasodilator in the arterial smooth muscles of the penis, making it erect for a period of time.

It should be noted that NO is released only in the presence of sexual stimulation. Otherwise, NO will not be released and the desired results will not be achieved.

Valif 20 mg is not usually affected by food or drink. However, in the case of fatty foods, alcohol, and grapefruit juice, Valif 20 mg interacts in the following ways:

Valif 20 mg with fatty foods

Fatty foods such as dairy products and meat tend to lengthen the Cmax of some medications. The impact restricts the uptake of drugs like generic Valif 20 mg and slows down its mechanism. Fatty foods slow down the typical process by almost an hour. Therefore, fatty foods should be avoided with these pills.

Valif 20 mg with alcohol

Alcohol causes a number of problems for Vardenafil to work properly. For example, alcohol in combination with Valif 20 mg causes dehydration, disrupts liver function, lowers blood pressure, and interferes with its metabolic process, reducing the overall effectiveness of the tablets.

Valif 20 mg with grapefruit juice

Grapefruit juice interferes with liver enzymes, specifically CYP3A4 and CYP2C9. It blocks liver enzymes. Liver enzymes are needed to break down and metabolize Vardenafil for absorption. However, since grapefruit juice has suppressed liver enzymes, Vardenafil cannot be broken down. Thus, the erection-enhancing action of the drug is eliminated.

You should keep the following in mind when storing Valif 20 mg:

• The medicine should be stored in a dry place, away from moisture.
• Store the medicine at room temperature, ideally between 15°C and 30°C.
• Keep the medicine in its container/package away from direct sunlight.
• Place the medicine in a safe place, out of the reach of children and pets.
• Validate the expiration date before purchasing and using it to avoid unfortunate circumstances.
• Dispose of the medicine properly. Do not flush it down the toilet as it is harmful to the environment.